关键信息
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基因名
IGF2R
- 应用
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别名
CD222; IGF2-R; CIMPR; M6P-R; MPRI; Cation-Independent Mannose-6 Phosphate Receptor; M6P/IGF2 receptor; 300 kDa mannose 6-phosphate receptor
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
P11717
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表达区间
Asn2167~Ala2442
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蛋白长度
Partial
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分子量
33kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
IGF2R, or Insulin-like Growth Factor 2 Receptor, is a critical protein involved in various physiological processes, including growth, development, and metabolism. It primarily acts by binding to insulin-like growth factor 2 (IGF2), facilitating its clearance from circulation and modulating cellular signaling pathways. Dysregulation of IGF2R has been implicated in numerous diseases, including cancer and metabolic disorders, making it a significant target for therapeutic interventions. Researchers have focused on characterizing the structure and function of IGF2R, as well as developing recombinant forms of the protein to study its biological roles and potential clinical applications. The production of IGF2R as a recombinant protein has enabled in-depth investigations into its interactions with ligands, its role in cellular signaling, and its utility as a biomarker for disease progression. Furthermore, recombinant IGF2R is being explored for its potential in targeted therapies, as it may serve to inhibit malignancies that exploit the IGF signaling pathway. Overall, the research on IGF2R recombinant protein encompasses fundamental biological insights and promising therapeutic avenues, underscoring its importance in the realms of cellular biology and medical research.
