Recombinant Human FLJ42875 Protein

Recombinant human FLJ42875 protein is a poorly characterized protein encoded by the FLJ42875 gene, initially identified through large-scale sequencing projects such as the HUGE database and FANTOM cDNA libraries. The gene, also labeled as C1orf123 (Chromosome 1 open reading frame 123), remains largely unstudied, with limited functional annotation in public databases like UniProt or NCBI. Its molecular features include a predicted molecular weight of ~20-25 kDa and putative structural domains inferred from sequence homology, though experimental validation is lacking. As a recombinant protein, FLJ42875 is typically produced in heterologous expression systems (e.g., E. coli or mammalian cells) with affinity tags (His-tag, GST) to facilitate purification and detection.

Current knowledge suggests potential involvement in basic cellular processes, possibly linked to RNA metabolism or protein-protein interactions based on weak homology to known nucleic acid-binding proteins. However, its exact biological role, subcellular localization, and post-translational modifications remain undefined. Research interest in this protein primarily stems from its inclusion in broad omics studies, where it appears as a differentially expressed candidate in specific pathological contexts, such as cancer or neurodegenerative diseases. Its recombinant form serves as a tool for antibody production, interactome mapping, or structural studies using techniques like crystallography or cryo-EM. The lack of functional data positions FLJ42875 as both a challenge and opportunity for exploratory research in protein characterization and pathway discovery.