| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | FOXR2 |
| Uniprot No | Q6PJQ5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-311aa |
| 氨基酸序列 | MDLKLKDCEFWYSLHGQVPGLLDWDMRNELFLPCTTDQCSLAEQILAKYRVGVMKPPEMPQKRRPSPDGDGPPCEPNLWMWVDPNILCPLGSQEAPKPSGKEDLTNISPFPQPPQKDEGSNCSEDKVVESLPSSSSEQSPLQKQGIHSPSDFELTEEEAEEPDDNSLQSPEMKCYQSQKLWQINNQEKSWQRPPLNCSHLIALALRNNPHCGLSVQEIYNFTRQHFPFFWTAPDGWKSTIHYNLCFLDSFEKVPDSLKDEDNARPRSCLWKLTKEGHRRFWEETRVLAFAQRERIQECMSQPELLTSLFDL |
| 分子量 | 59.95 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人FOXR2蛋白的3篇模拟参考文献示例(实际文献需通过学术数据库验证，以下内容仅供格式参考)：
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1. **文献名称**：*FOXR2 promotes oncogenic properties in neuroblastoma via transcriptional regulation of cell migration genes*
**作者**：Smith J. et al.
**摘要**：研究报道了重组人FOXR2蛋白在神经母细胞瘤中的功能，发现其通过激活与细胞迁移相关的靶基因(如MMP9)驱动肿瘤侵袭性，提示FOXR2可能成为癌症治疗靶点。
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2. **文献名称**：*Structural and functional characterization of recombinant human FOXR2 protein*
**作者**：Zhang L. et al.
**摘要**：该文献利用大肠杆菌系统成功表达并纯化了重组人FOXR2蛋白，通过晶体学解析其三维结构，揭示了其DNA结合结构域的关键氨基酸残基，为后续功能研究奠定基础。
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3. **文献名称**：*FOXR2 regulates Wnt/β-catenin signaling in hepatocellular carcinoma*
**作者**：Kim S. & Lee H.
**摘要**：研究通过重组FOXR2蛋白的体外实验，证实其通过与β-catenin相互作用增强Wnt通路活性，促进肝癌细胞增殖，为靶向FOXR2的癌症疗法提供了理论依据。
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**注**：以上文献为模拟示例，实际研究中建议通过PubMed、Web of Science等平台以关键词“recombinant human FOXR2”“FOXR2 function”等检索最新文献。若需具体文献辅助，可提供更详细的研究方向。
Forkhead box R2 (FOXR2) is a member of the forkhead box (FOX) protein family, characterized by a conserved DNA-binding domain termed the "forkhead" or "winged-helix" motif. FOX proteins are transcription regulators involved in diverse cellular processes, including development, metabolism, and cancer. Human FOXR2. encoded by the *FOXR2* gene, remains less studied compared to other FOX members but has gained attention for its potential roles in oncogenesis and neurological disorders. Structurally, FOXR2 contains a forkhead domain near its N-terminus, critical for DNA interaction and transcriptional activity.
Recombinant human FOXR2 protein is engineered using expression systems (e.g., *E. coli* or mammalian cells) to produce purified, functional protein for research. Its recombinant form enables studies on molecular mechanisms, such as DNA-binding specificity, protein-protein interactions, and regulatory pathways. Emerging evidence links FOXR2 to cancer progression, particularly in neuroblastoma and glioblastoma, where it may promote tumor cell survival or metastasis. It is also implicated in neurodevelopment, with aberrant expression observed in neuropsychiatric conditions.
Despite its potential significance, FOXR2's exact biological functions and regulatory networks remain unclear. Current research focuses on elucidating its targets, post-translational modifications, and crosstalk with signaling pathways like Wnt or PI3K/AKT. Recombinant FOXR2 tools are vital for high-throughput screening, structural studies, and therapeutic exploration, though challenges persist in resolving its context-dependent roles and tissue-specific regulation.
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