| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | HEAB |
| Uniprot No | Q92989 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-425aa |
| 氨基酸序列 | MGEEANDDKKPTTKFELERETELRFEVEASQSVQLELLTGMAEIFGTELTRNKKFTFDAGAKVAVFTWHGCSVQLSGRTEVAYVSKDTPMLLYLNTHTALEQMRRQAEKEEERGPRVMVVGPTDVGKSTVCRLLLNYAVRLGRRPTYVELDVGQGSVSIPGTMGALYIERPADVEEGFSIQAPLVYHFGSTTPGTNIKLYNKITSRLADVFNQRCEVNRRASVSGCVINTCGWVKGSGYQALVHAASAFEVDVVVVLDQERLYNELKRDLPHFVRTVLLPKSGGVVERSKDFRRECRDERIREYFYGFRGCFYPHAFNVKFSDVKIYKVGAPTIPDSCLPLGMSQEDNQLKLVPVTPGRDMVHHLLSVSTAEGTEENLSETSVAGFIVVTSVDLEHQVFTVLSPAPRPLPKNFLLIMDIRFMDLK |
| 分子量 | 74 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人HEAB蛋白的假设性参考文献示例(基于科学文献常见结构虚构，供格式参考)：
---
1. **文献名称**: *Heterologous Expression and Functional Characterization of Recombinant Human HEAB Protein in E. coli*
**作者**: Zhang L, Wang Y, Chen R
**摘要**: 本研究利用大肠杆菌系统成功表达了重组人HEAB蛋白，通过Ni柱亲和层析纯化后获得了高纯度蛋白。Western blot分析证实其与天然HEAB的抗原性一致。功能实验表明该重组蛋白具有ATP结合活性，暗示其在细胞内能量代谢中可能发挥作用。
2. **文献名称**: *Structural Insights into HEAB Protein: Role in Cancer Cell Proliferation*
**作者**: Gupta S, Tanaka M, Lee JS
**摘要**: 通过X射线晶体学解析了重组人HEAB蛋白的三维结构，揭示了其特殊的核苷酸结合域。体外细胞实验表明，HEAB过表达显著促进肺癌细胞增殖，提示其可能作为肿瘤治疗的潜在靶点。
3. **文献名称**: *Development of a HEAB-Specific Monoclonal Antibody Using Recombinant Protein as Immunogen*
**作者**: Müller P, Schmidt E, Klein H
**摘要**: 以重组人HEAB蛋白为抗原制备了高特异性单克隆抗体。抗体在ELISA和免疫组化中表现优异，适用于检测HEAB在多种组织中的表达分布，为临床病理研究提供工具。
---
**注意**：以上文献为示例，实际研究中应确保引用真实存在的资料。若“HEAB蛋白”名称有误或为特定领域术语，建议核实拼写或补充背景信息后重新检索(如：确认是否为HE4、HepaB或HABP等类似缩写)。
Human HEAB (HEBP2), a 21-kDa protein encoded by the HEBP2 gene, belongs to the heme-binding protein family. Initially identified for its ability to interact with heme and porphyrins, it plays a regulatory role in heme homeostasis, oxidative stress responses, and cellular iron metabolism. Structurally, HEAB contains a conserved heme-binding domain critical for its function in scavenging free heme, a pro-oxidant implicated in inflammation and tissue damage. Dysregulation of HEAB expression has been linked to pathologies like cancer, neurodegeneration, and hemolytic disorders. Recombinant human HEAB protein is typically produced in Escherichia coli or mammalian expression systems, enabling studies on its molecular interactions, antioxidant mechanisms, and therapeutic potential. Current research explores its utility in mitigating heme-induced cytotoxicity, modulating inflammatory pathways, and developing diagnostic biomarkers for conditions involving heme dysregulation. Its recombinant form also serves as a tool for structural analysis and drug discovery targeting heme-related diseases.
×
