| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | HOXC6 |
| Uniprot No | P09630 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-235aa |
| 氨基酸序列 | MNSYFTNPSLSCHLAGGQDVLPNVALNSTAYDPVRHFSTYGAAVAQNRIYSTPFYSPQENVVFSSSRGPYDYGSNSFYQEKDMLSNCRQNTLGHNTQTSIAQDFSSEQGRTAPQDQKASIQIYPWMQRMNSHSGVGYGADRRRGRQIYSRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKESNLTSTLSGGGGGATADSLGGKEEKREETEEEKQKE |
| 分子量 | 53.3 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下为3篇关于重组人HOXC6蛋白的参考文献示例(注：部分内容为假设性概括，实际文献需通过学术数据库查询确认)：
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1. **文献名称**: *HOXC6 promotes epithelial-mesenchymal transition in breast cancer through Wnt/β-catenin pathway*
**作者**: Li Y, Wang J, et al.
**摘要**: 本研究通过原核表达系统获得重组人HOXC6蛋白，发现其能激活Wnt/β-catenin信号通路，促进乳腺癌细胞上皮-间质转化(EMT)，增强肿瘤转移能力。
2. **文献名称**: *Recombinant HOXC6 enhances proliferation of prostate cancer cells by upregulating Cyclin D1*
**作者**: Smith RP, Brown KT, et al.
**摘要**: 利用哺乳动物细胞表达系统制备重组HOXC6蛋白，证实其通过直接结合Cyclin D1启动子区域，刺激前列腺癌细胞周期进展及增殖。
3. **文献名称**: *Purification and functional analysis of recombinant HOXC6 in adipocyte differentiation*
**作者**: Zhang L, Xu H, et al.
**摘要**: 通过大肠杆菌表达并纯化HOXC6重组蛋白，发现其抑制前脂肪细胞分化关键转录因子PPARγ的表达，提示HOXC6在代谢调控中的潜在作用。
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**建议**：如需真实文献，可在PubMed或Web of Science中以“recombinant HOXC6 protein”“HOXC6 expression and purification”为关键词检索，并筛选涉及蛋白制备、功能机制或疾病关联的研究。
**Background of Recombinant Human HOXC6 Protein**
The HOXC6 protein, a member of the homeobox (HOX) gene family, plays critical roles in embryonic development, particularly in regulating axial patterning, limb formation, and organogenesis. HOX genes encode transcription factors that guide spatial and temporal cell differentiation by modulating downstream target genes. HOXC6 is located on chromosome 12q13.13 and is involved in mesenchymal-epithelial interactions, influencing processes such as skeletal development, adipogenesis, and hematopoiesis.
Dysregulation of HOXC6 has been implicated in several pathologies, including cancers (e.g., prostate, breast, and colorectal), where it may act as an oncogene by promoting cell proliferation, migration, and resistance to apoptosis. Its expression is also linked to metabolic disorders and fibrosis.
Recombinant human HOXC6 protein is engineered *in vitro* using expression systems (e.g., *E. coli* or mammalian cells) to produce a purified, bioactive form for research. This allows studies on its DNA-binding properties, interaction with co-factors (e.g., PBX or MEIS proteins), and regulatory mechanisms in development and disease. Current research focuses on elucidating HOXC6’s role in signaling pathways (e.g., Wnt, BMP) and its potential as a therapeutic target. Structural analyses of the recombinant protein further aid in understanding its functional domains and designing targeted interventions.
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