| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | HRMT1L6 |
| Uniprot No | Q96LA8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-375aa |
| 氨基酸序列 | MSQPKKRKLE SGGGGEGGEG TEEEDGAERE AALERPRRTK RERDQLYYEC YSDVSVHEEM IADRVRTDAY RLGILRNWAA LRGKTVLDVG AGTGILSIFC AQAGARRVYA VEASAIWQQA REVVRFNGLE DRVHVLPGPV ETVELPEQVD AIVSEWMGYG LLHESMLSSV LHARTKWLKE GGLLLPASAE LFIAPISDQM LEWRLGFWSQ VKQHYGVDMS CLEGFATRCL MGHSEIVVQG LSGEDVLARP QRFAQLELSR AGLEQELEAG VGGRFRCSCY GSAPMHGFAI WFQVTFPGGE SEKPLVLSTS PFHPATHWKQ ALLYLNEPVQ VEQDTDVSGE ITLLPSRDNP RRLRVLLRYK VGDQEEKTKD FAMED |
| 分子量 | 41.9 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
由于“重组人HRMT1L6蛋白”可能是一个虚构或拼写错误的蛋白名称(目前无公开文献记录)，目前无法提供真实参考文献。以下为虚构示例，仅供参考格式与内容：
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1. **文献名称**：Expression and Functional Analysis of Recombinant Human HRMT1L6 Protein
**作者**：Smith J, et al.
**摘要**：研究报道了通过大肠杆菌系统成功表达重组人HRMT1L6蛋白，并验证其作为组蛋白甲基转移酶的活性，提示其在表观遗传调控中的作用。
2. **文献名称**：Structural Characterization of HRMT1L6 and Its Role in Cellular Differentiation
**作者**：Lee S, et al.
**摘要**：通过X射线晶体学解析了HRMT1L6的结构，发现其催化结构域与肿瘤发生相关，重组蛋白可诱导干细胞分化。
3. **文献名称**：HRMT1L6 Knockdown Alters DNA Repair Pathways in Human Cells
**作者**：Zhang Y, et al.
**摘要**：利用重组HRMT1L6蛋白进行体外实验，发现其通过甲基化修饰影响BRCA1介导的DNA修复机制。
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**建议**：
1. 核实蛋白名称的正确性(可能为**PRMT1**、**HNMT**等同家族蛋白的误写)。
2. 在PubMed或Google Scholar中检索类似关键词(如“重组甲基转移酶”“重组人蛋白甲基化”)。
Recombinant human HRMT1L6 protein is a genetically engineered form of the histone-arginine methyltransferase 1-like 6 (HRMT1L6), an enzyme implicated in post-translational modification of histones. This protein belongs to the protein arginine methyltransferase (PRMT) family, which catalyzes the transfer of methyl groups to arginine residues on histone and non-histone substrates, modulating chromatin structure, gene expression, and cellular processes like DNA repair and signal transduction. HRMT1L6 is speculated to play roles in epigenetic regulation, though its specific substrates and biological functions remain less characterized compared to other PRMTs.
The recombinant version is typically produced in expression systems (e.g., *E. coli* or mammalian cells) to ensure high purity and activity for research applications. It enables studies on enzymatic mechanisms, substrate specificity, and interactions with downstream targets. Interest in HRMT1L6 stems from the broader significance of PRMTs in diseases, including cancer, neurodegeneration, and cardiovascular disorders, where aberrant arginine methylation is linked to pathological gene regulation. Investigating recombinant HRMT1L6 may uncover its role in these pathways, potentially identifying therapeutic targets. Current research focuses on clarifying its structural domains, catalytic activity, and physiological relevance, bridging gaps in understanding arginine methylation's diverse regulatory impacts.
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