| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | NEGR1 |
| Uniprot No | Q7Z3B1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 38-324 aa |
| 活性数据 | VDF PWAAVDNMMV RKGDTAVLRC YLEDGASKGA WLNRSSIIFA GGDKWSVDPR VSISTLNKRD YSLQIQNVDV TDDGPYTCSV QTQHTPRTMQ VHLTVQVPPK IYDISNDMTV NEGTNVTLTC LATGKPEPSI SWRHISPSAK PFENGQYLDI YGITRDQAGE YECSAENDVS FPDVRKVKVV VNFAPTIQEI KSGTVTPGRS GLIRCEGAGV PPPAFEWYKG EKKLFNGQQG IIIQNFSTRS ILTVTNVTQE HFGNYTCVAA NKLGTTNASL PLNPPSTAQY GITG |
| 分子量 | 38.7 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是与重组人NEGR1蛋白相关的3篇参考文献及摘要概括：
1. **文献名称**：*NEGR1 regulates cortical neuron migration through cell-cell adhesion*
**作者**：Park C et al.
**摘要**：研究通过重组表达人NEGR1蛋白，揭示了其在皮质神经元迁移中的作用，证明NEGR1通过调控细胞间黏附促进神经元的定向迁移。
2. **文献名称**：*Recombinant NEGR1 protein enhances neurite outgrowth and synaptic connectivity in vitro*
**作者**：Deckmann I et al.
**摘要**：研究利用重组NEGR1蛋白处理神经元，发现其能显著增强神经突生长和突触形成，提示其在神经发育中的功能。
3. **文献名称**：*NEGR1 variants and their association with obesity-related traits: Functional studies using recombinant protein models*
**作者**：Willer CJ et al.
**摘要**：通过重组NEGR1蛋白功能分析，探讨了特定基因变异如何影响蛋白结构及其在肥胖相关代谢途径中的潜在机制。
(注：以上文献为示例，实际研究中建议查阅最新权威数据库获取准确信息。)
Neuronal Growth Regulator 1 (NEGR1), a member of the immunoglobulin (Ig) superfamily, is a glycosylphosphatidylinositol (GPI)-anchored cell adhesion protein encoded by the *NEGR1* gene in humans. It belongs to the IgLON family, characterized by three Ig-like domains that mediate homophilic and heterophilic interactions, influencing neurite outgrowth, synaptic plasticity, and neuronal connectivity. Predominantly expressed in the brain, particularly in the hippocampus, cortex, and cerebellum, NEGR1 plays critical roles in neural development, including neuronal migration, axon guidance, and synaptogenesis. Studies link its function to modulating extracellular matrix interactions and regulating signaling pathways involved in neurodevelopment.
Beyond its neurological roles, NEGR1 is implicated in metabolic regulation. Genome-wide association studies (GWAS) connect *NEGR1* variants to obesity and body mass index (BMI), suggesting its involvement in energy homeostasis. Dysregulation of NEGR1 has also been associated with neuropsychiatric disorders, such as depression, schizophrenia, and autism spectrum disorders, though molecular mechanisms remain under investigation. Recombinant NEGR1 protein, typically produced in mammalian or insect expression systems, is utilized in functional studies to dissect its adhesive properties, receptor interactions, and downstream signaling. Its potential as a therapeutic target or biomarker in neurological and metabolic diseases continues to be explored.
×
