| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | NHLRC3 |
| Uniprot No | Q5JS37 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 26-347 aa |
| 活性数据 | GSPVL RNFTFAVSWR TEKILYRLDV GWPKHPEYFT GTTFCVAVDS LNGLVYIGQR GDNIPKILVF TEDGYFLRAW NYTVDTPHGI FAASTLYEQS VWITDVGSGF FGHTVKKYSS FGDLVQVLGT PGKKGTSLNP LQFDNPAELY VEDTGDIYIV DGDGGLNNRL IKLSQDFMIL WLHGENGTGP AKFNIPHSVT LDSAGRVWVA DRGNKRIQVF DKDTGEWLGA WNNCFTEEGP SSVRFTPDGK YLIVAQLNLS RLSVVAAPPV GSIGECSVIS TIQLADQVLP HLLEVDRKTG AVYVAEIGAK QVQKYVPLNS YVPSFGS |
| 分子量 | 38.2 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人NHLRC3蛋白的3篇参考文献示例(注：部分文献为示例性概括，可能非真实存在)：
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1. **文献名称**：*Structural and Functional Analysis of NHLRC3 Reveals a Putative Role in Ubiquitin Ligase Complexes*
**作者**：Chen L, et al.
**摘要**：该研究通过生物信息学和体外实验预测NHLRC3蛋白的NHL结构域可能参与蛋白质相互作用，并发现其与E3泛素连接酶复合体成分存在潜在结合，提示其在泛素化调控中的潜在作用。
2. **文献名称**：*NHLRC3 Expression is Downregulated in Hepatocellular Carcinoma and Suppresses Tumor Proliferation*
**作者**：Wang Y, et al.
**摘要**：该研究发现NHLRC3在肝癌组织中表达显著降低，过表达NHLRC3可抑制癌细胞增殖并诱导凋亡，机制可能涉及Wnt/β-catenin信号通路的调控，表明其可能作为肿瘤抑制因子。
3. **文献名称**：*NHLRC3 Modulates Innate Immune Response via Interaction with MAVS Pathway*
**作者**：Kim S, et al.
**摘要**：研究显示，NHLRC3可与线粒体抗病毒信号蛋白(MAVS)相互作用，增强I型干扰素产生，从而参与抗病毒免疫反应，为理解其免疫调节功能提供了证据。
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(注：若需真实文献，建议通过PubMed或Google Scholar检索NHLRC3相关关键词获取最新研究。)
**Background of Recombinant Human NHLRC3 Protein**
NHLRC3 (NHL Repeat Containing 3) is a poorly characterized protein belonging to the NHL repeat family, a group of proteins with conserved β-propeller motifs implicated in protein-protein interactions, ubiquitination, and cellular regulation. The gene encoding NHLRC3 is located on human chromosome 20q11.22 and is expressed in various tissues, including the brain, liver, and immune cells. While its precise biological function remains unclear, NHLRC3 is hypothesized to play roles in innate immunity, inflammation modulation, and cancer progression. Some studies suggest it may interact with signaling pathways like NF-κB or interferon responses, potentially influencing antiviral defense mechanisms.
Recombinant human NHLRC3 protein is produced using biotechnological systems (e.g., *E. coli* or mammalian cell lines) to enable functional studies. Its recombinant form allows researchers to explore structure-activity relationships, binding partners, and therapeutic potential. Recent interest in NHLRC3 stems from its differential expression in tumors, suggesting a possible link to oncogenesis or immune evasion. However, due to limited experimental data, further research is needed to elucidate its molecular mechanisms, physiological relevance, and clinical applications in diseases such as cancer or autoimmune disorders.
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