| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | NRBP2 |
| Uniprot No | Q9NSY0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-501 aa |
| 活性数据 | MAAPEPAPRR ARERERERED ESEDESDILE ESPCGRWQKR REQVNQGNMP GLQSTFLAMD TEEGVEVVWN ELHFGDRKAF AAHEEKIQTV FEQLVLVDHP NIVKLHKYWL DTSEACARVI FITEYVSSGS LKQFLKKTKK NHKAMNARAW KRWCTQILSA LSFLHACSPP IIHGNLTSDT IFIQHNGLIK IGSVWHRIFS NALPDDLRSP IRAEREELRN LHFFPPEYGE VADGTAVDIF SFGMCALEMA VLEIQTNGDT RVTEEAIARA RHSLSDPNMR EFILCCLARD PARRPSAHSL LFHRVLFEVH SLKLLAAHCF IQHQYLMPEN VVEEKTKAMD LHAVLAELPR PRRPPLQWRY SEVSFMELDK FLEDVRNGIY PLMNFAATRP LGLPRVLAPP PEEVQKAKTP TPEPFDSETR KVIQMQCNLE RSEDKARWHL TLLLVLEDRL HRQLTYDLLP TDSAQDLASE LVHYGFLHED DRMKLAAFLE STFLKYRGTQ A |
| 分子量 | 57.8 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人NRBP2蛋白的3篇参考文献(虚构示例，供参考格式)：
1. **文献名称**: *NRBP2 modulates Wnt/β-catenin signaling by interacting with Dishevelled*
**作者**: Smith A, et al.
**摘要**: 研究揭示了NRBP2通过结合Dishevelled蛋白调控Wnt信号通路的分子机制，并通过重组NRBP2蛋白实验证实其抑制结肠癌细胞增殖的作用。
2. **文献名称**: *Recombinant human NRBP2 promotes hepatocellular carcinoma metastasis via PI3K/AKT activation*
**作者**: Chen L, et al.
**摘要**: 通过表达纯化重组NRBP2蛋白，发现其能激活PI3K/AKT通路，增强肝癌细胞侵袭能力，提示其作为潜在治疗靶点。
3. **文献名称**: *Structural and functional analysis of NRBP2 in neurodegenerative disorders*
**作者**: Gomez M, et al.
**摘要**: 利用重组NRBP2蛋白的晶体结构解析，揭示其与tau蛋白的相互作用，并探讨其在阿尔茨海默病中调控神经元凋亡的病理机制。
(注：以上文献为模拟内容，实际研究中建议通过PubMed或Web of Science查询真实文献。)
Recombinant human NRBP2 (Nuclear Receptor Binding Protein 2) is a ubiquitously expressed adaptor protein involved in regulating diverse cellular processes, including signal transduction, cell proliferation, and metabolic homeostasis. It contains conserved domains such as a ubiquitin-associated (UBA) domain, a protein kinase C conserved region 2 (C2) domain, and multiple SH3-binding motifs, enabling interactions with kinases, ubiquitin ligases, and nuclear receptors. NRBP2 plays a role in modulating key pathways like Wnt/β-catenin and mTOR signaling, impacting cell growth, differentiation, and apoptosis. Studies suggest its dual regulatory functions in cancer, acting as either an oncogene or tumor suppressor depending on cellular context. Dysregulation of NRBP2 has been linked to malignancies, neurodegenerative disorders, and metabolic syndromes. Recombinant NRBP2 is commonly produced in Escherichia coli or mammalian expression systems for structural and functional studies. Its applications span in vitro protein interaction assays, enzymatic activity analysis (e.g., kinase cascades), and drug discovery platforms targeting signaling networks. Recent crystallographic studies have begun elucidating its 3D architecture and binding interfaces, providing insights for therapeutic intervention. The protein's multifaceted roles continue to make it a focus in understanding disease mechanisms and developing precision medicine strategies.
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