| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | NRM |
| Uniprot No | Q8IXM6 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-262 aa |
| 活性数据 | MAPALLLIPAALASFILAFGTGVEFVRFTSLRPLLGGIPESGGPDARQGWLAALQDRSILAPLAWDLGLLLLFVGQHSLMAAERVKAWTSRYFGVLQRSLYVACTALALQLVMRYWEPIPKGPVLWEARAEPWATWVPLLCFVLHVISWLLIFSILLVFDYAELMGLKQVYYHVLGLGEPLALKSPRALRLFSHLRHPVCVELLTVLWVVPTLGTDRLLLAFLLTLYLGLAHGLDQQDLRYLRAQLQRKLHLLSRPQDGEAE |
| 分子量 | 55.8 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人(NRM)蛋白的3-4篇参考文献的简要总结(文献为虚构示例，仅作参考)：
1. **文献名称**：**"Recombinant Human NRM Protein: Expression in E. coli and Functional Characterization"**
**作者**：Li, X. et al.
**摘要**：该研究通过大肠杆菌表达系统成功获得重组人NRM蛋白，并优化了纯化流程。实验表明，NRM在体外能够抑制肿瘤细胞增殖，可能与调控MAPK信号通路相关。
2. **文献名称**：**"Structural Insights into NRM-mediated Apoptosis in Breast Cancer Cells"**
**作者**：Wang, Y. & Chen, J.
**摘要**：通过X射线晶体学解析了NRM蛋白的三维结构，并发现其通过结合Bcl-2家族蛋白诱导乳腺癌细胞凋亡，为靶向治疗提供了新方向。
3. **文献名称**：**"NRM as a Novel Biomarker: Clinical Correlation in Neurodegenerative Diseases"**
**作者**：Smith, R. et al.
**摘要**：研究证实重组NRM蛋白在阿尔茨海默症患者脑脊液中显著低表达，其水平与认知功能下降呈负相关，提示其作为神经退行性疾病诊断标志物的潜力。
4. **文献名称**：**"Engineering Recombinant NRM for Enhanced Stability and Drug Delivery"**
**作者**：Zhang, H. et al.
**摘要**：通过定点突变改良NRM蛋白的热稳定性，并构建纳米颗粒载药系统，显著提高了其在动物模型中的抗肿瘤效果和血液循环时间。
(注：以上文献为模拟生成，实际研究请参考权威数据库如PubMed、Web of Science等。)
**Background of Recombinant Human NRM Protein**
Recombinant human NRM (Nucleoredoxin-like protein) is a genetically engineered protein derived from the human NRM gene, which encodes a redox-regulated enzyme belonging to the thioredoxin superfamily. Naturally, NRM plays a pivotal role in cellular redox homeostasis and signaling pathways, particularly in modulating oxidative stress responses and regulating key processes such as apoptosis, cell proliferation, and differentiation. It interacts with signaling molecules like Dishevelled (Dvl) in the Wnt/β-catenin pathway, influencing developmental and disease-related mechanisms.
Dysregulation of NRM has been implicated in pathologies including cancer, neurodegenerative disorders, and inflammatory diseases, highlighting its potential as a therapeutic target. Recombinant NRM production, achieved via bacterial or mammalian expression systems, enables large-scale, high-purity protein synthesis for research and drug development. This engineered form retains the native protein’s functional properties, facilitating studies on its structural dynamics, redox activity, and molecular interactions.
Researchers utilize recombinant NRM to explore its role in oxidative stress mitigation, signaling crosstalk, and disease mechanisms, offering insights into novel antioxidant therapies or targeted treatments. Its availability accelerates drug screening and mechanistic studies, bridging gaps between biochemical research and clinical applications. By providing a consistent, contaminant-free protein source, recombinant NRM serves as a vital tool in understanding redox biology and advancing precision medicine.
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