| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | OR2M3 |
| Uniprot No | Q8NG83 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-312 aa |
| 活性数据 | MARENSTFNSDFILLGIFNHSPTHTFLFFLVLAIFSVAFMGNSVMVLLIYLDTQLHTPMY LLLSQLSLMDLMLICTTVPKMAFNYLSGSKSISMAGCATQIFFYTSLLGSECFLLAVMAY DRYTAICHPLRYTNLMSPKICGLMTAFSWILGSTDGIIDVVATFSFSYCGSREIAHFFCD FPSLLILSCSDTSIFEKILFICCIVMIVFPVAIIIASYARVILAVIHMGSGEGRRKAFTT CSSHLLVVGMYYGAALFMYIRPTSDRSPTQDKMVSVFYTILTPMLNPLIYSLRNKEVTRA FMKILGKGKSGE |
| 分子量 | 34.8 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人OR2M3蛋白的假设性参考文献示例(请注意，部分文献信息为模拟内容，实际引用需通过学术数据库核实)：
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1. **文献名称**: *"OR2M3 as a Key Mediator of Hexanoic Acid Detection in Human Olfaction"*
**作者**: Smith J, et al.
**摘要**: 研究通过体外表达系统证实OR2M3受体特异性响应短链脂肪酸(如己酸)，揭示其在人类嗅觉中对特定食物相关气味分子的识别机制。
2. **文献名称**: *"Non-Olfactory Expression of OR2M3 in Gastrointestinal Tissues and Its Metabolic Implications"*
**作者**: Chen L, Wang H.
**摘要**: 发现OR2M3在肠道上皮细胞中异常表达，可能通过调节脂肪酸代谢信号通路影响营养吸收，提示其非嗅觉生理功能。
3. **文献名称**: *"Genetic Variation in OR2M3 and Its Association with Olfactory Dysfunction in Parkinson’s Disease"*
**作者**: Müller R, et al.
**摘要**: 通过群体遗传学分析，指出OR2M3基因多态性与帕金森病患者嗅觉减退的显著相关性，为疾病早期诊断提供潜在生物标志物。
4. **文献名称**: *"Structural Insights into OR2M3 Activation Mechanism via Cryo-EM"*
**作者**: Zhang Y, et al.
**摘要**: 利用冷冻电镜解析OR2M3与其激动剂结合的活性构象，阐明该受体在配体识别后的跨膜信号传导结构基础。
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**注意**：以上文献为示例，实际研究中请通过PubMed、Web of Science等平台以“OR2M3”、“olfactory receptor”等关键词检索最新文献。
Olfactory receptor 2M3 (OR2M3) is a member of the olfactory receptor (OR) family, which constitutes the largest group of G protein-coupled receptors (GPCRs) in humans. These receptors are primarily involved in detecting odorants and mediating olfactory signaling. OR2M3 is encoded by the OR2M3 gene located on chromosome 1 and is classically associated with odorant recognition, particularly volatile compounds. Unlike many ORs that are pseudogenized in humans, OR2M3 remains functional, suggesting potential roles beyond olfaction. Recent studies have identified its expression in non-olfactory tissues, such as the liver, kidney, and testes, hinting at broader physiological or pathological functions, including metabolic regulation or cellular communication.
Recombinant OR2M3 protein is artificially produced using expression systems like HEK293 or insect cells to enable structural and functional studies. Its recombinant form allows researchers to investigate ligand-binding specificity, activation mechanisms, and downstream signaling pathways. Structural analyses reveal characteristic features of GPCRs, including seven transmembrane domains and extracellular ligand-binding pockets. Challenges in recombinant production include ensuring proper membrane localization and post-translational modifications for functional activity.
Research on recombinant OR2M3 holds therapeutic potential, as ORs are increasingly linked to diseases like cancer and metabolic disorders. It also serves as a tool for decoding human olfaction complexity and developing biosensors for odorant detection. Further studies aim to uncover its extra-olfactory roles and therapeutic applications.
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