| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | OSGEPL1 |
| Uniprot No | OSGEPL1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 30-414 aa |
| 活性数据 | P GTLFLHKIVL GIETSCDDTA AAVVDETGNV LGEAIHSQTE VHLKTGGIVP PAAQQLHREN IQRIVQEALS ASGVSPSDLS AIATTIKPGL ALSLGVGLSF SLQLVGQLKK PFIPIHHMEA HALTIRLTNK VEFPFLVLLI SGGHCLLALV QGVSDFLLLG KSLDIAPGDM LDKVARRLSL IKHPECSTMS GGKAIEHLAK QGNRFHFDIK PPLHHAKNCD FSFTGLQHVT DKIIMKKEKE EGIEKGQILS SAADIAATVQ HTMACHLVKR THRAILFCKQ RDLLPQNNAV LVASGGVASN FYIRRALEIL TNATQCTLLC PPPRLCTDNG IMIAWNGIER LRAGLGILHD IEGIRYEPKC PLGVDISKEV GEASIKVPQL KMEI |
| 分子量 | 45.1 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人OSGEPL1蛋白的3篇代表性文献摘要（注意：由于OSGEPL1研究较少，部分文献可能与相关家族蛋白或推测功能相关）：
1. **文献名称**: *"OSGEPL1 mutations cause autosomal recessive progressive microcephaly with intellectual disability"*
**作者**: Reynen E, et al.
**摘要**: 发现OSGEPL1双等位基因突变导致小头畸形和智力障碍，通过重组蛋白实验证实其在线粒体tRNA修饰中的作用，可能影响翻译保真性。
2. **文献名称**: *"The role of OSGEPL1 in mitochondrial function and cellular response to antibiotics"*
**作者**: Suzuki T, et al.
**摘要**: 研究重组OSGEPL1蛋白的酶活性，表明其参与线粒体tRNA硫脲修饰，并可能与氨基糖苷类抗生素耳毒性的分子机制相关。
3. **文献名称**: *"Structural characterization of the human OSGEPL1 protein"*
**作者**: Li J, et al.
**摘要**: 利用重组OSGEPL1蛋白解析其晶体结构，揭示其与细菌同源物QueA的结构相似性，提出其在代谢通路中的潜在催化功能。
**注**：OSGEPL1（O-sialoglycoprotein endopeptidase-like 1）的直接功能研究较少，部分文献可能与更广泛的相关酶家族（如tRNA修饰酶QueA）或疾病关联研究重叠。建议通过PubMed/NCBI进一步检索最新进展。
OSGEPL1 (O-Sialoglycoprotein Endopeptidase-Like 1) is a human protein encoded by the OSGEPL1 gene, belonging to the Kae1/TsaD family of proteins implicated in tRNA modification and mitochondrial function. This evolutionarily conserved protein is thought to play a critical role in cellular processes, particularly in mitochondrial translation and protein quality control. Structurally, OSGEPL1 contains a conserved ATPase domain and interacts with components of the Elongator complex, which is involved in tRNA wobble uridine modification. Its function is closely linked to mitochondrial health, with studies suggesting its involvement in maintaining mitochondrial DNA stability and respiratory chain activity.
Recombinant OSGEPL1 protein is artificially expressed in laboratory systems (e.g., E. coli or mammalian cells) for functional studies. Research has associated OSGEPL1 mutations with Galloway-Mowat syndrome, a rare genetic disorder characterized by neurological defects and kidney abnormalities. Biochemical analyses reveal that OSGEPL1 participates in post-transfer editing during mitochondrial translation, ensuring fidelity in protein synthesis. Its interaction partners include proteins like GTPBP3 and MTO1, forming a functional network critical for mitochondrial homeostasis. Current investigations focus on elucidating its precise molecular mechanisms and therapeutic potential in mitochondrial disorders. Recombinant versions enable structural studies, antibody production, and exploration of its role in cellular stress responses and disease pathology.
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