| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | PCDHGC5 |
| Uniprot No | Q9Y5F6 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-878 aa |
| 活性数据 | MGPKTLPQLAGKWQVLCMLSLCCWGWVSGQLRYSVVEESEPGTLVGNVAQDLGLKMTDLLSRRLQLGSEENGRYFSLSLMSGALAVNQKIDRESLCGASTSCLLPVQVVTEHPLELIRVEVEILDLNDNSPSFATPEREMRISESAASGARFPLDSAQDPDVGTNTVSFYTLSPNSHFSLNVKTLKDGKPFPELVLEQQLDREAQARHQLVLTAVDGGTPARSGTTLISVIVLDINDNAPTFQSSVLRVGIPENAPIGTLLLRLNATDPDEGTNGQLDYSFGDHTSEAVRNLFGLDPSSGAIHVLGPIDFEESRFYEIHARARDQGQPAMEGHCVIQVDVGDVNDNAPEVLLASLANPVLESTPVGTVVGLFNVRDRDSGRNGEVSLDISPDLPFQIKPSENHYSLLTSQPLDREATSHYIIELLASDAGSPSLHKHLTIRLNISDVNDNAPRFNQQLYTAYILENRPPGSLLCTVAASDPDTGDNARLTYSIVGNQVQGAPASSFVYVNPEDGRIFAQRTFDYELLQMLQIVVGVRDSGSPPLHANTSLHVFVLDENDNAPAVLHPRPDWEHSAPQRLPRSAPPGSLVTKVTAVDADAGHNAWLSYSLLPQSTAPGLFLVSTHTGEVRTARALLEDDSDTQQVVVLVRDNGDPSLSSTATVLLVLEDEDPEEMPKSSDFLIHPPERSDLTLYLIVALATVSLLSLVTFTFLSAKCLQGNADGDGGGGQCCRRQDSPSPDFYKQSSPNLQVSSDGTLKYMEVTLRPTDSQSHCYRTCFSPASDGSDFTFLRPLSVQQPTALALEPDAIRSRSNTLRERSQVRGSAPPRATPGGGTGEAARPHKGLNLHPLLSGRLGRWLRSTRFSGSLDRLRETRVAD |
| 分子量 | 121.6 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是模拟生成的关于重组人PCDHGC5蛋白的参考文献示例(供参考，实际文献需查询数据库)：
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1. **文献名称**：*Structural insights into the homophilic complex of human PCDHGC5 extracellular domains*
**作者**：Zhang Y, et al.
**摘要**：本研究通过重组表达人PCDHGC5的胞外结构域，利用X射线晶体学解析其三维结构，揭示了其同源二聚化的分子机制，为原钙黏蛋白介导的细胞黏附提供了结构基础。
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2. **文献名称**：*PCDHGC5 knockdown promotes tumor invasion via Wnt/β-catenin pathway in colorectal cancer*
**作者**：Li H, et al.
**摘要**：通过重组PCDHGC5蛋白体外功能实验，发现其通过抑制Wnt/β-catenin信号通路调控结直肠癌细胞迁移，提示其作为肿瘤抑制因子的潜在作用。
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3. **文献名称**：*Recombinant human PCDHGC5 induces synaptic plasticity in hippocampal neurons*
**作者**：Wang J, et al.
**摘要**：利用HEK293细胞重组表达PCDHGC5蛋白，验证其可促进海马神经元突触可塑性，并调控神经突起的生长，为神经发育障碍研究提供新方向。
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4. **文献名称**：*Proteolytic processing of PCDHGC5 regulates its adhesive function*
**作者**：Kim S, et al.
**摘要**：研究重组PCDHGC5蛋白的酶切修饰机制，发现金属蛋白酶ADAM10对其胞外域的剪切可调控细胞黏附功能，影响胚胎发育过程中的细胞迁移。
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**注**：以上文献为模拟生成，真实研究需通过PubMed、Web of Science等平台检索关键词(如“PCDHGC5 recombinant protein”“protocadherin gamma”)。原钙黏蛋白γ亚家族成员多与神经系统及癌症相关，建议结合具体研究方向筛选文献。
Protocadherin gamma subfamily C, member 5 (PCDHGC5) is a member of the clustered protocadherin (PCDH) gamma gene cluster, which belongs to the cadherin superfamily of calcium-dependent cell adhesion proteins. As a transmembrane protein, PCDHGC5 contains seven extracellular cadherin repeats, a transmembrane domain, and a cytoplasmic tail with conserved motifs that mediate intracellular signaling. It plays critical roles in neuronal development, including axon guidance, synaptic connectivity, and neural circuit formation. The gamma-protocadherins are particularly known for their combinatorial diversity, generated through alternative splicing of variable exons, enabling the establishment of complex neural networks by promoting self-avoidance and dendritic tiling.
Recombinant human PCDHGC5 protein is typically produced in heterologous expression systems (e.g., mammalian cells) to study its homophilic binding specificity, structural features, and role in cell-cell recognition. Dysregulation of PCDHGC5 has been implicated in neurodevelopmental disorders and cancers, with studies suggesting its involvement in tumor suppression or metastasis modulation depending on cellular context. Recent research also explores its potential as a biomarker in neurological diseases. However, challenges remain in characterizing its isoform-specific functions due to the high homology within the PCDH gamma cluster and technical limitations in isolating individual variants. This recombinant tool facilitates mechanistic studies on neural wiring and disease pathogenesis.
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