关键信息
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基因名
RABGGTB
- 应用
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别名
RABGGTB; GGTB; Geranylgeranyl transferase type-2 subunit beta; EC 2.5.1.60; Geranylgeranyl transferase type II subunit beta; GGTase-II-beta; Rab geranyl-geranyltransferase subunit beta; Rab GG transferase beta; Rab GGTase beta; Rab geranylgeranyltransferase subunit beta; Type II protein geranyl-geranyltransferase subunit beta
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P53611
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表达区间
2-331 aa
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氨基酸序列
GTPQKDVII KSDAPDTLLL EKHADYIASY GSKKDDYEYC MSEYLRMSGI YWGLTVMDLM GQLHRMNREE ILAFIKSCQH ECGGISASIG HDPHLLYTLS AVQILTLYDS INVIDVNKVV EYVKGLQKED GSFAGDIWGE IDTRFSFCAV ATLALLGKLD AINVEKAIEF VLSCMNFDGG FGCRPGSESH AGQIYCCTGF LAITSQLHQV NSDLLGWWLC ERQLPSGGLN GRPEKLPDVC YSWWVLASLK IIGRLHWIDR EKLRNFILAC QDEETGGFAD RPGDMVDPFH TLFGIAGLSL LGEEQIKPVN PVFCMPEEVL QRVNVQPELV S
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分子量
36.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
RABGGTB, or Rab geranylgeranyl transferase beta, is an enzyme that plays a crucial role in the post-translational modification of Rab proteins, which are essential regulators of intracellular trafficking. These proteins are involved in various cellular processes, including vesicle transport, membrane fusion, and signal transduction. The proper functioning of Rab proteins is critical for maintaining cellular homeostasis, and aberrations in their geranylgeranylation can lead to various pathologies, including cancer and neurodegenerative disorders. Research on RABGGTB has gained momentum as scientists aim to better understand its biochemical mechanisms and regulatory pathways, which could uncover potential therapeutic targets. The study of RABGGTB also involves exploring its interactions with other cellular proteins and its role in the broader context of Rab protein networks. This research has important implications for developing strategies to manipulate Rab protein function in disease contexts, thereby opening avenues for targeted therapies. Additionally, advancements in biotechnology and molecular biology techniques have enabled researchers to explore recombinant expression systems for RABGGTB, facilitating detailed structural and functional analyses. Overall, the investigation into RABGGTB is an exciting frontier in cellular and molecular biology, with the potential to impact diverse fields such as drug development and gene therapy.
