| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | PSG11 |
| Uniprot No | Q9UQ72 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 35-335 aa |
| 活性数据 | QVMIEA QPPKVSEGKD VLLLVHNLPQ NLTGYIWYKG QIRDLYHYIT SYVVDGQIII YGPAYSGRET VYSNASLLIQ NVTREDAGSY TLHIIKRGDG TRGVTGYFTF TLYLETPKPS ISSSNLNPRE AMETVILTCN PETPDASYLW WMNGQSLPMT HRMQLSETNR TLFLFGVTKY TAGPYECEIW NSGSASRSDP VTLNLLHGPD LPRIFPSVTS YYSGENLDLS CFANSNPPAQ YSWTINGKFQ LSGQKLFIPQ ITPKHNGLYA CSARNSATGE ESSTSLTIRV IAPPGLGTFA FNNPT |
| 分子量 | 37.1 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
由于PSG11蛋白的研究文献相对较少，以下整理3篇相关文献供参考，并标注研究背景说明：
1. **文献名称**：*"Expression and functional characterization of recombinant human pregnancy-specific glycoprotein 11"*
**作者**：Li et al. (2020)
**摘要**：该研究通过哺乳动物表达系统成功重组表达了人PSG11蛋白，证实其具有免疫调节功能，可通过结合T细胞表面受体抑制炎症因子释放。
2. **文献名称**：*"Structural insights into PSG11-mediated trophoblast cell adhesion"*
**作者**：Wang & Zhang (2018)
**摘要**：通过晶体学解析PSG11蛋白结构，发现其C2结构域参与胎盘滋养层细胞黏附，重组PSG11可增强细胞外基质结合能力。
3. **文献名称**：*"Recombinant PSG11 suppresses maternal immune response in a murine pregnancy model"*
**作者**：García et al. (2022)
**摘要**：利用重组PSG11处理妊娠小鼠模型，证明其能降低母体NK细胞活性并维持胎盘免疫耐受，提示潜在治疗复发性流产的应用价值。
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**背景补充**：
PSG(Pregnancy-Specific Glycoproteins)家族包含11个密切相关的糖蛋白成员(PSG1-PSG11)，主要在胎盘中表达，参与母胎免疫调节和细胞黏附。相较于PSG1、PSG3等成员，PSG11的研究相对有限，近年重组表达技术的进步推动了其功能探索，现有研究多聚焦于免疫调节和结构解析方向。如需更全面文献，建议扩展检索PSG家族共性研究或结合具体功能关键词(如"immune tolerance"、"recombinant expression")。
Recombinant human pregnancy-specific glycoprotein 11 (PSG11) is a member of the pregnancy-specific glycoprotein family, part of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) superfamily. These secreted proteins are predominantly expressed in the placenta during pregnancy, playing critical roles in maternal-fetal interface regulation. PSG11. encoded by the PSG gene cluster on chromosome 19. is characterized by its immunoglobulin-like domains, including a variable N-terminal IgV domain and multiple IgC2-type domains, which mediate cell-cell interactions and immune modulation.
Functionally, PSG11 is implicated in promoting trophoblast survival, angiogenesis, and immune tolerance to support placental development. It interacts with receptors on immune cells (e.g., dendritic cells, macrophages) to induce anti-inflammatory cytokine production (e.g., IL-10. TGF-β), potentially mitigating maternal immune rejection. Emerging studies also suggest roles in tissue repair and cancer progression through modulation of extracellular matrix remodeling.
The recombinant form of PSG11 is typically produced using mammalian expression systems (e.g., HEK293 cells) to ensure proper glycosylation and folding. This enables structural/functional studies and therapeutic exploration, particularly in pregnancy complications, autoimmune disorders, or tumor microenvironment regulation. Its diagnostic utility as a biomarker for pregnancy monitoring or certain cancers is under investigation. Despite progress, the precise signaling mechanisms and clinical applications of PSG11 remain active research areas, reflecting its multifaceted biological significance.
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