| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | RBM42 |
| Uniprot No | Q9BTD8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 2-480 aa |
| 活性数据 | AGAGPAPGL PGAGGPVVPG PGAGIPGKSG EERLKEMEAE MALFEQEVLG APVPGIPTAV PAVPTVPTVP TVEAMQVPAA PVIRPIIATN TYQQVQQTLE ARAAAAATVV PPMVGGPPFV GPVGFGPGDR SHLDSPEARE AMFLRRAAVA PQRAPILRPA FVPHVLQRAD SALSSAAAGP RPMALRPPHQ ALVGPPLPGP PGPPMMLPPM ARAPGPPLGS MAALRPPLEE PAAPRELGLG LGLGLKEKEE AVVAAAAGLE EASAAVAVGA GGAPAGPAVI GPSLPLALAM PLPEPEPLPL PLEVVRGLLP PLRIPELLSL RPRPRPPRPE PPPGLMALEV PEPLGEDKKK GKPEKLKRCI RTAAGSSWED PSLLEWDADD FRIFCGDLGN EVNDDILARA FSRFPSFLKA KVIRDKRTGK TKGYGFVSFK DPSDYVRAMR EMNGKYVGSR PIKLRKSMWK DRNLDVVRKK QKEKKKLGLR |
| 分子量 | 50.4 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是几篇与重组人RBM42蛋白相关的模拟参考文献(请注意，实际文献可能需通过学术数据库验证或补充)：
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1. **文献名称**: "RBM42 regulates RNA splicing and interacts with the SMN complex in motor neurons"
**作者**: Li, Y., et al. (2020)
**摘要**: 本研究揭示了RBM42在RNA剪接中的作用，证明其通过与SMN(脊髓性肌萎缩症相关蛋白)复合物相互作用调控运动神经元中的mRNA加工，突变可能导致神经肌肉疾病。
2. **文献名称**: "Structural characterization of the RNA-binding motif protein RBM42 and its role in cell cycle control"
**作者**: Zhang, H., et al. (2019)
**摘要**: 通过晶体学解析了RBM42的RNA结合结构域结构，发现其通过结合特定mRNA序列影响细胞周期相关基因的表达，提示其在肿瘤发生中的潜在调控功能。
3. **文献名称**: "A novel RBM42 mutation linked to neurodevelopmental disorders disrupts mRNA stability"
**作者**: Chen, J., et al. (2021)
**摘要**: 首次报道了RBM42基因突变与儿童神经发育障碍的相关性，突变破坏了RBM42维持mRNA稳定性的能力，导致神经元分化异常。
4. **文献名称**: "RBM42 mediates stress granule formation and cellular stress response in cancer cells"
**作者**: Wang, Q., et al. (2018)
**摘要**: 研究表明RBM42在癌细胞应激颗粒组装中起关键作用，敲低RBM42会抑制细胞应对氧化应激的能力，影响肿瘤细胞的生存和化疗耐药性。
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**提示**：以上为模拟内容，实际文献请通过PubMed、Google Scholar等平台以“RBM42”或“RNA-binding motif protein 42”为关键词检索。如需具体文献，建议结合研究方向补充关键词(如癌症、神经疾病等)。
RBM42 (RNA-binding motif protein 42) is a conserved eukaryotic protein encoded by the RBM42 gene, primarily recognized for its role in RNA metabolism and post-transcriptional regulation. Belonging to the RNA-binding protein family, it contains an RNA recognition motif (RRM) domain that facilitates interactions with RNA molecules, including mRNA, and participates in processes such as splicing, stability control, and translational regulation. Studies suggest RBM42 is involved in early embryonic development, neuronal function, and cellular stress responses. Dysregulation of RBM42 has been linked to neurodevelopmental disorders, including intellectual disability and microcephaly, as well as certain cancers. Recombinant human RBM42 protein, typically produced via bacterial or mammalian expression systems, enables in vitro studies to dissect its molecular mechanisms, binding partners, and structural features. Its recombinant form is instrumental in investigating pathogenic mutations (e.g., missense variants affecting RRM domain integrity) and developing diagnostic or therapeutic strategies. Current research focuses on elucidating its interplay with spliceosome components, RNA substrates, and disease-associated pathways, positioning RBM42 as a potential biomarker or target for RNA-centric therapies.
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