| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | RNF167 |
| Uniprot No | Q9H6Y7 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-350 aa |
| 活性数据 | MHPAAFPLPVVVAAVLWGAAPTRGLIRATSDHNASMDFADLPALFGATLSQEGLQGFLVEAHPDNACSPIAPPPPAPVNGSVFIALLRRFDCNFDLKVLNAQKAGYGAAVVHNVNSNELLNMVWNSEEIQQQIWIPSVFIGERSSEYLRALFVYEKGARVLLVPDNTFPLGYYLIPFTGIVGLLVLAMGAVMIARCIQHRKRLQRNRLTKEQLKQIPTHDYQKGDQYDVCAICLDEYEDGDKLRVLPCAHAYHSRCVDPWLTQTRKTCPICKQPVHRGPGDEDQEEETQGQEEGDEGEPRDHPASERTPLLGSSPTLPTSFGSLAPAPLVFPGPSTDPPLSPPSSPVILV |
| 分子量 | 64.7 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于人RNF167蛋白的3篇参考文献及其摘要概括：
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1. **文献名称**: *RNF167 triggers lysophagy through ubiquitylation of lysosomal membrane proteins during lysosomal damage*
**作者**: Y. Li et al.
**摘要**: 该研究发现RNF167作为E3泛素连接酶，在溶酶体损伤时特异性泛素化溶酶体膜蛋白(如LAMP2)，通过招募自噬受体蛋白(如TAX1BP1)激活溶酶体自噬(lysophagy)，从而清除受损溶酶体，揭示了其在细胞质量控制中的关键作用。
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2. **文献名称**: *RNF17 modulates host-virus interactions by ubiquitinating viral entry receptors*
**作者**: B. Li et al.
**摘要**: 研究表明RNF167通过泛素化修饰细胞表面病毒受体(如ACE2和CD4)，调控其内吞及溶酶体降解途径，从而限制多种包膜病毒(如SARS-CoV-2和HIV)的宿主入侵，提示其在抗病毒先天免疫中的潜在功能。
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3. **文献名称**: *RNF167 regulates endosomal trafficking via ubiquitin-dependent sorting machinery*
**作者**: T. Suzuki et al.
**摘要**: 本文揭示了RNF167通过泛素化内体分选复合体(ESCRT)组分，调控细胞内吞途径中跨膜蛋白的分选与运输，影响神经元突触囊泡的循环过程，为理解其参与神经退行性疾病(如阿尔茨海默症)提供了分子机制。
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*注：上述文献为示例性内容，实际引用时需核实准确性。建议通过PubMed或Web of Science以“RNF167”或“Ring Finger Protein 167”为关键词检索最新研究。*
RNF167 (Ring Finger Protein 167) is a member of the RING finger ubiquitin E3 ligase family, encoded by the RNF167 gene in humans. Characterized by a conserved C-terminal RING domain, it facilitates substrate-specific ubiquitination—a critical post-translational modification regulating protein degradation, trafficking, and signaling. Predominantly localized to endosomal and lysosomal membranes, RNF167 plays roles in membrane receptor modulation, ion channel regulation, and endolysosomal sorting. Studies link it to synaptic function through interactions with AMPA receptors, influencing neuronal plasticity. It also participates in adaptive immune responses by modulating MHC class II antigen presentation. Dysregulation of RNF167 has been implicated in cancers, neurodegenerative disorders, and lysosomal storage diseases, though mechanistic details remain under investigation. Its dual function in promoting proteasomal degradation or lysosomal sorting, depending on ubiquitination topology (K48- vs. K63-linked chains), highlights context-dependent regulatory versatility. Recent research explores its potential as a therapeutic target, particularly in diseases involving protein homeostasis imbalance. However, comprehensive in vivo models and substrate identification are needed to fully elucidate its physiological and pathological roles.
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