| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | S100A7L2 |
| Uniprot No | Q5SY68 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-101 aa |
| 活性数据 | MNIPLGEKVM LDIVAMFRQY SGDDGRMDMP GLVNLMKENF PNFLSGCEKS DMDYLSNALE KKDDNKDKKV NYSEFLSLLG DITIDHHKIM HGVAPCSGGS Q |
| 分子量 | 11.3 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人S100A7L2蛋白的3篇文献摘要示例(基于公开信息整理，文献为虚构示例，供参考)：
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1. **文献名称**：*"Expression and functional characterization of recombinant human S100A7L2 in inflammatory models"*
**作者**：Zhang L, et al.
**摘要**：本研究成功在大肠杆菌中表达并纯化了重组人S100A7L2蛋白，发现其可通过激活NF-κB通路促进角质形成细胞的炎症反应，提示其在银屑病等炎症性皮肤病中的潜在作用。
2. **文献名称**：*"Structural analysis of S100A7L2 reveals zinc-binding properties distinct from S100A7"*
**作者**：Wang Y, et al.
**摘要**：通过X射线晶体学解析S100A7L2的三维结构，发现其独特的锌离子结合位点，区别于同家族S100A7蛋白，可能影响其与靶蛋白(如RAGE受体)的相互作用机制。
3. **文献名称**：*"S100A7L2 promotes keratinocyte differentiation via ERK signaling pathway"*
**作者**：Chen X, et al.
**摘要**：重组S100A7L2蛋白能诱导人永生化角质形成细胞(HaCaT)的分化，并通过ERK磷酸化调控相关基因表达，为皮肤屏障修复提供新靶点。
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**注意**：以上文献为示例，实际研究中可查阅 **PubMed**(https://pubmed.ncbi.nlm.nih.gov/)或 **Google Scholar** 输入关键词 **"S100A7L2 recombinant"** 或 **"S100A7L2 function"** 获取真实文献。若该蛋白研究较少，可扩展至同家族蛋白(如S100A7)的综述性论文。
S100A7L2. a member of the S100 calcium-binding protein family, is a recently characterized protein encoded within the Epidermal Differentiation Complex (EDC) on human chromosome 1q21. This genomic region is critical for epidermal barrier formation and immune regulation. S100A7L2 shares structural homology with other S100 proteins, featuring two EF-hand calcium-binding motifs. However, it exhibits distinct functional properties compared to its paralogs, such as S100A7 (psoriasin) and S100A15. Predominantly expressed in skin keratinocytes and certain mucosal tissues, S100A7L2 is implicated in innate immunity, inflammation, and epithelial differentiation. Its expression is modulated by microbial challenges, cytokines, and barrier disruption, suggesting roles in pathogen defense and tissue repair. Studies highlight its antimicrobial activity against bacteria and fungi, likely mediated through zinc sequestration or direct microbial membrane interaction. In inflammatory skin disorders like psoriasis, S100A7L2 expression correlates with disease severity, potentially serving as a biomarker. Recombinant S100A7L2 protein, typically produced via bacterial or mammalian expression systems, enables functional studies to unravel its signaling pathways (e.g., NF-κB modulation) and receptor interactions. Despite progress, its full spectrum of biological roles and therapeutic potential in chronic inflammation, cancer, or infection remains under investigation, necessitating further mechanistic and translational research.
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