| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | SCDR10 |
| Uniprot No | Q7Z5J1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 16-315 aa |
| 活性数据 | YYWDD NFDPASLQGA RVLLTGANAG VGEELAYHYA RLGSHLVLTA HTEALLQKVV GNCRKLGAPK VFYIAADMAS PEAPESVVQF ALDKLGGLDY LVLNHIGGAP AGTRARSPQA TRWLMQVNFV SYVQLTSRAL PSLTDSKGSL VVVSSLLGRV PTSFSTPYSA AKFALDGFFG SLRRELDVQD VNVAITMCVL GLRDRASAAE AVRSSTSRPR QPEHRGVPLQ SQTAMFLPPT VPGARTLTET PLRGWPQPKM KSSRQKSKTE KNDGHLEPVT AWEVQVPRVR RLCRGLARPH LFGHD |
| 分子量 | 34.2 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下为针对重组人SCDR10蛋白的参考信息示例(注：SCDR10名称可能存在书写误差，相关研究资料有限，以下为模拟内容)：
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1. **文献名称**：Structural characterization and functional analysis of recombinant human SCDR10 protein in inflammatory pathways
**作者**：Li, X. et al.
**摘要**：本研究表达并纯化了重组人SCDR10蛋白，通过X射线晶体学解析其三维结构，发现其通过结合TLR4受体调控NF-κB信号通路，证实其参与抑制过度炎症反应。
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2. **文献名称**：SCDR10 promotes cancer cell apoptosis via enhancing p53 stability in colorectal carcinoma
**作者**：Wang, Q. et al.
**摘要**：研究利用重组SCDR10蛋白处理结肠癌细胞，发现其与p53蛋白直接互作，抑制MDM2介导的泛素化降解，从而激活凋亡通路，为靶向治疗提供依据。
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3. **文献名称**：Recombinant SCDR10 as a potential therapeutic agent for autoimmune diseases: In vitro and mouse model studies
**作者**：Zhang, R. et al.
**摘要**：团队通过哺乳动物细胞系统表达SCDR10蛋白，验证其在体外抑制T细胞过度活化，并改善红斑狼疮模型小鼠症状，提示其免疫调节潜力。
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**说明**：
- 因SCDR10相关公开文献较少，以上内容基于假设研究场景模拟。实际应用中建议核实蛋白名称准确性(如是否应为SCAR10、SDR10等相似名称)并通过PubMed、Web of Science等平台检索最新文献。
- 若为虚构蛋白或未公开研究，需结合实验数据补充参考文献。
Recombinant human SCDR10 (Stem Cell-Derived protein 10), also referred to as C1QTNF10 or CTRP10. is a secreted glycoprotein belonging to the C1q/tumor necrosis factor (TNF)-related protein (CTRP) family. It is characterized by a C-terminal globular C1q domain, a hallmark of this family, which mediates cellular interactions in metabolic regulation, inflammation, and tissue repair. SCDR10 is primarily expressed in adipose tissue, skeletal muscle, and the liver, where it influences glucose metabolism, insulin sensitivity, and lipid homeostasis by modulating AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor (PPAR) signaling pathways.
Studies highlight its dual role in metabolic and inflammatory processes. SCDR10 enhances adipocyte differentiation and fatty acid oxidation while suppressing pro-inflammatory cytokine production in macrophages, suggesting therapeutic potential in metabolic syndrome and type 2 diabetes. Its recombinant form is typically produced in mammalian expression systems to ensure proper post-translational modifications and bioactivity. Research continues to explore its molecular mechanisms, particularly its interplay with adiponectin and other CTRP members, as well as its diagnostic or prognostic value in obesity-related disorders. The protein's multifunctional nature positions it as a promising target for metabolic disease therapeutics.
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