| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | SLMO2 |
| Uniprot No | Q9Y3B1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-194 aa |
| 活性数据 | MKIWTSEHVF DHPWETVTTA AMQKYPNPMN PSVVGVDVLD RHIDPSGKLH SHRLLSTEWG LPSIVKSLIG RTKTYVQE HSVVDPVEKT MELKSTNISF TNMVSVDERL IYKPHPQDPE KTVLTQEAII TVKGVSLSSY LEGLMASTIS SNASKGREAM EWVIHKLNAE IEELTASARG TIRTPM FAEK |
| 分子量 | 21.4 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是基于合理推测整理的3篇可能与重组人SLMO2蛋白相关的假设性文献示例(注：SLMO2名称可能存在误差，建议确认基因/蛋白名称的准确性)：
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1. **文献名称**：*"Recombinant Human SLMO2 Facilitates Mitochondrial Cytochrome C Assembly"*
**作者**：Smith A. et al.
**摘要**：本研究报道了重组人SLMO2蛋白作为线粒体硫醇氧化酶，在细胞色素C成熟过程中的关键作用。实验证实SLMO2通过氧化线粒体内膜的亚硫酸盐，促进硫醇-二硫键交换，从而支持细胞色素C的折叠与功能。
2. **文献名称**：*"In Vitro Transport Activity of SLMO2 in Organic Anion Uptake"*
**作者**：Johnson R. et al.
**摘要**：通过在HEK293细胞中表达重组SLMO2蛋白，作者证明其能够介导特定有机阴离子的跨膜转运，并受pH值调节，提示SLMO2可能在药物代谢及肝/肠吸收中具有潜在应用价值。
3. **文献名称**：*"SLMO2 Knockdown Alters Cellular Redox Homeostasis"*
**作者**：Wang L. et al.
**摘要**：利用CRISPR技术结合重组蛋白回补实验，揭示了SLMO2通过调控谷胱甘肽氧化还原平衡影响肿瘤细胞凋亡，为靶向癌症治疗的策略提供了新视角。
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**重要提示**：
- 上述文献为假设示例，实际研究中"SLMO2"可能存在命名混淆(如正确基因符号可能为**SLCO2B1**或**SELENOF**等)。
- 建议通过**PubMed/UniProt**等数据库以"SLCO2B1"或全称检索，或进一步验证目标蛋白的基因符号及功能背景。
**Background of Recombinant Human SLMO2 Protein**
SLMO2 (Solute Carrier Family 25 Member 52) is a mitochondrial carrier protein encoded by the *SLC25A52* gene in humans. It belongs to the solute carrier 25 (SLC25) family, which facilitates the transport of nucleotides, metabolites, and cofactors across the mitochondrial inner membrane. Structurally, SLMO2 contains six transmembrane domains and conserved carrier motifs critical for substrate recognition and transport. While its exact physiological substrates remain under investigation, SLMO2 is hypothesized to participate in mitochondrial energy metabolism, potentially transporting adenosine monophosphate (AMP) or other nucleotides to maintain nucleotide homeostasis.
Studies suggest SLMO2 is ubiquitously expressed, with elevated levels in tissues with high metabolic demands, such as the liver, heart, and kidneys. Dysregulation of SLMO2 has been linked to cancer progression, where it may influence apoptosis resistance and bioenergetic adaptation in tumor cells. Additionally, SLMO2 interacts with proteins like adenine nucleotide translocase (ANT), hinting at a role in mitochondrial permeability transition pore regulation.
Recombinant human SLMO2 protein, produced via *E. coli* or mammalian expression systems, enables functional and structural studies to elucidate its transport mechanisms and pathological relevance. Its applications span enzyme activity assays, interaction studies, and drug discovery targeting mitochondrial dysfunction-related diseases.
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