| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | SUDS3 |
| Uniprot No | Q9H7L9 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 2-328 aa |
| 活性数据 | SAAGLLAPA PAQAGAPPAP EYYPEEDEEL ESAEDDERSC RGRESDEDTE DASETDLAKH DEEDYVEMKE QMYQDKLASL KRQLQQLQEG TLQEYQKRMK KLDQQYKERI RNAELFLQLE TEQVERNYIK EKKAAVKEFE DKKVELKENL IAELEEKKKM IENEKLTMEL TGDSMEVKPI MTRKLRRRPN DPVPIPDKRR KPAPAQLNYL LTDEQIMEDL RTLNKLKSPK RPASPSSPEH LPATPAESPA QRFEARIEDG KLYYDKRWYH KSQAIYLESK DNQKLSCVIS SVGANEIWVR KTSDSTKMRI YLGQLQRGLF VIRRRSAA |
| 分子量 | 38.1 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下为3-4篇与SUDS3蛋白相关的代表性文献及摘要概括：
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1. **文献名称**: *SUDS3 interacts with the SUMO ligase PIASy and regulates apoptosis in human cells*
**作者**: K. Li et al.
**摘要**: 研究发现SUDS3通过结合SUMO连接酶PIASy参与调控细胞凋亡途径。SUDS3缺失导致p53依赖的凋亡信号增强，提示其在抑制肿瘤发生中的潜在作用。
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2. **文献名称**: *Structural basis of SUDS3-SIN3 interaction and its role in histone deacetylation*
**作者**: M. L. Vural et al.
**摘要**: 通过X射线晶体学解析SUDS3与SIN3复合体结构，揭示了二者协同调节组蛋白去乙酰化酶(HDAC)活性的分子机制，为表观遗传调控提供结构依据。
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3. **文献名称**: *SUDS3 deficiency induces genomic instability via impaired DNA damage repair in mouse embryonic stem cells*
**作者**: T. Nakagawa et al.
**摘要**: 在小鼠胚胎干细胞中敲除SUDS3基因，发现其通过影响SIN3-HDAC复合体功能，导致DNA损伤修复能力下降和基因组稳定性降低，影响多能性维持。
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4. **文献名称**: *Epigenetic regulation of breast cancer metastasis by SUDS3-mediated chromatin remodeling*
**作者**: S. R. Patel et al.
**摘要**: 研究证明乳腺癌中SUDS3表达与转移相关，其通过重塑染色质结构调控EMT(上皮间质转化)相关基因，提示SUDS3作为癌症治疗靶点的潜力。
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注：以上文献及内容为模拟示例，实际研究请参考具体学术数据库(如PubMed或Web of Science)。
SUDS3 (SAS-3 Deubiquitination Complex Subunit 3), also known as SAP45 or SPT7. is a conserved nuclear protein that plays critical roles in chromatin remodeling, transcriptional regulation, and genomic stability. It is a key component of the histone deacetylase (HDAC)-dependent SIN3 transcriptional corepressor complex, which regulates gene expression by modifying chromatin structure. SUDS3 mediates interactions between SIN3 and other regulatory proteins, facilitating HDAC recruitment to target genes for histone deacetylation and transcriptional repression. Additionally, SUDS3 is implicated in the DNA damage response, where it participates in DNA repair pathways and maintains genome integrity. Studies suggest its involvement in cell cycle progression, apoptosis, and cellular differentiation. Dysregulation of SUDS3 has been linked to cancer progression, neurodegenerative disorders, and developmental abnormalities. Structurally, SUDS3 contains a coiled-coil domain and intrinsically disordered regions, enabling flexible binding with multiple partners. Its functional diversity underscores its importance in both normal physiology and disease, making it a potential therapeutic target. Recent research continues to explore its mechanisms in epigenetic regulation and cellular stress responses.
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