| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | SUSD2 |
| Uniprot No | Q9UGT4 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-822 aa |
| 活性数据 | MKPALLPWALLLLATALGPGPGPTADAQESCSMRCGALDGPCSCHPTCSGLGTCCLDFRDFCLEILPYSGSMMGGKDFVVRHFKMSSPTDASVICRFKDSIQTLGHVDSSGQVHCVSPLLYESGRIPFTVSLDNGHSFPRAGTWLAVHPNKVSMMEKSELVNETRWQYYGTANTSGNLSLTWHVKSLPTQTITIELWGYEETGMPYSQEWTAKWSYLYPLATHIPNSGSFTFTPKPAPPSYQRWRVGALRIIDSKNYAGQKDVQALWTNDHALAWHLSDDFREDPVAWARTQCQAWEELEDQLPNFLEELPDCPCTLTQARADSGRFFTDYGCDMEQGSVCTYHPGAVHCVRSVQASLRYGSGQQCCYTADGTQLLTADSSGGSTPDRGHDWGAPPFRTPPRVPSMSHWLYDVLSFYYCCLWAPDCPRYMQRRPSNDCRNYRPPRLASAFGDPHFVTFDGTNFTFNGRGEYVLLEAALTDLRVQARAQPGTMSNGTETRGTGLTAVAVQEGNSDVVEVRLANRTGGLEVLLNQEVLSFTEQSWMDLKGMFLSVAAGDRVSIMLASGAGLEVSVQGPFLSVSVLLPEKFLTHTHGLLGTLNNDPTDDFTLHSGRVLPPGTSPQELFLFGANWTVHNASSLLTYDSWFLVHNFLYQPKHDPTFEPLFPSETTLNPSLAQEAAKLCGDDHFCNFDVAATGSLSTGTATRVAHQLHQRRMQSLQPVVSCGWLAPPPNGQKEGNRYLAGSTIYFHCDNGYSLAGAETSTCQADGTWSSPTPKCQPGRSYAVLLGIIFGGLAVVAAVALVYVLLRRRKGNTHVWGAQP |
| 分子量 | 116.6 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人SUSD2蛋白的3篇代表性文献的简要概括：
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1. **文献名称**: *SUSD2 suppresses tumor progression and predicts survival in cervical cancer*
**作者**: Chen et al. (2020)
**摘要**: 研究发现SUSD2通过抑制Wnt/β-catenin信号通路，抑制宫颈癌细胞增殖和转移。重组SUSD2蛋白体外实验显示其抑制肿瘤细胞侵袭及诱导凋亡的作用，提示其潜在治疗价值。
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2. **文献名称**: *Recombinant SUSD2 alters extracellular vesicle cargo to inhibit breast cancer migration*
**作者**: Smith et al. (2018)
**摘要**: 通过哺乳动物细胞表达重组SUSD2蛋白，发现其能调控乳腺癌细胞分泌的外泌体蛋白成分，抑制细胞迁移及血管生成，可能与整合素信号通路相关。
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3. **文献名称**: *SUSD2 as a novel biomarker for mesenchymal stem cell characterization*
**作者**: Nakamura et al. (2017)
**摘要**: 该研究开发了昆虫细胞表达的重组SUSD2蛋白，证实其作为间充质干细胞的表面标志物功能，可通过激活Notch通路促进干细胞自我更新。
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注：以上为示例性文献，实际检索时需通过数据库(如PubMed)以"SUSD2 recombinant protein"等关键词验证最新研究。
SUSD2 (Sushi Domain Containing 2) is a transmembrane protein belonging to the complement regulatory protein family. It is characterized by extracellular sushi-like domains, which are evolutionarily conserved structural motifs involved in protein-protein interactions. SUSD2 is expressed in various tissues, including the placenta, immune cells, and certain cancers, where it plays roles in immune regulation and cellular signaling. Studies suggest its involvement in modulating immune responses, particularly in inhibiting T-cell activation, potentially contributing to immune evasion in cancers like ovarian and breast tumors.
The protein has gained attention for its dual roles in cancer biology. While some research indicates tumor-suppressive functions via Wnt signaling pathway inhibition, other studies highlight its pro-tumorigenic effects through interactions with the tumor microenvironment. Recombinant human SUSD2 protein is typically produced in mammalian expression systems (e.g., HEK293 cells) to ensure proper glycosylation and structural integrity. This recombinant form facilitates functional studies, antibody development, and therapeutic exploration.
Emerging applications include its use as a biomarker for cancer prognosis and as a potential therapeutic target. Despite progress, the molecular mechanisms underlying SUSD2's context-dependent roles remain partially unresolved, driving ongoing research into its signaling networks and clinical relevance in immunotherapy and regenerative medicine.
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