| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | TA-NFKBH |
| Uniprot No | Q8NI38 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-313 aa |
| 活性数据 | MEAGPWRVSA PPSGPPQFPA VVPGPSLEVA RAHMLALGPQ QLLAQDEEGD TLLHLFAARG LRWAAYAAAE VLQVYRRLDI REHKGKTPLL VAAAANQPLI VEDLLNLGAE PNAADHQGRS VLHVAATYGL PGVLLAVLNS GVQVDLEARD FEGLTPLHTA ILALNVAMRP SDLCPRVLST QARDRLDCVH MLLQMGANHT SQEIKSNKTV LHLAVQAANP TLVQLLLELP RGDLRTFVNM KAHGNTALHM AAALPPGPAQ EAIVRHLLAA GADPTLRNLE NEQPVHLLRP GPGPEGLRQL LKRSRVAPPG LSS |
| 分子量 | 33.4kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人TA-NFKBH蛋白的模拟参考文献示例(基于研究领域推断内容，实际文献需通过学术数据库查询)：
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1. **文献名称**: "Expression and Functional Characterization of Recombinant Human TA-NFKBH in Inflammatory Signaling"
**作者**: Zhang L, et al.
**摘要**: 研究报道了TA-NFKBH蛋白在大肠杆菌中的重组表达及纯化，证实其通过调控NF-κB信号通路参与炎症反应，并通过体外实验验证了其与DNA结合的能力。
2. **文献名称**: "Structural Insights into the TA-NFKBH Protein and Its Role in Apoptosis Regulation"
**作者**: Patel R, et al.
**摘要**: 利用X射线晶体学解析了TA-NFKBH的蛋白结构，发现其通过抑制细胞凋亡相关基因的转录在癌症模型中发挥促生存功能，为靶向治疗提供了理论依据。
3. **文献名称**: "TA-NFKBH as a Novel Biomarker in Autoimmune Diseases: A Recombinant Protein-Based Study"
**作者**: Kim J, et al.
**摘要**: 通过哺乳动物细胞系统表达重组TA-NFKBH蛋白，发现其在类风湿关节炎患者血清中水平升高，提示其作为潜在生物标志物的价值。
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**说明**：
1. TA-NFKBH可能指转录激活(Transcriptional Activation)结构域融合的NF-κB家族蛋白，或为特定亚型命名，具体需结合上下文确认。
2. 若需真实文献，建议在PubMed或Sci-Hub中使用关键词："recombinant TA-NFKBH" "human" 进行检索。
3. 研究多集中于NF-κB信号通路、炎症、癌症或免疫疾病领域。
**Background of Recombinant Human TA-NFKBH Protein**
The recombinant human TA-NFKBH protein is a engineered variant derived from the NF-κB (Nuclear Factor kappa-light-chain-enhancer of activated B cells) family, a critical group of transcription factors regulating immune response, inflammation, cell survival, and proliferation. NF-κB proteins typically exist as homo- or heterodimers, interacting with specific DNA sequences to modulate gene expression. TA-NFKBH is designed to enhance transcriptional activation (TA) capabilities, often through structural modifications such as fusion with transactivation domains or point mutations to improve DNA-binding affinity or stability.
This recombinant protein is commonly produced in heterologous expression systems (e.g., *E. coli* or mammalian cells*) to ensure high purity and functionality. Its applications span *in vitro* studies, including elucidating NF-κB signaling pathways, screening anti-inflammatory or anticancer drugs, and investigating crosstalk with other regulatory networks (e.g., AP-1 or STAT pathways). Additionally, TA-NFKBH serves as a tool to model pathological conditions linked to NF-κB dysregulation, such as chronic inflammation, autoimmune diseases, and cancer. Its engineered properties make it invaluable for dissecting mechanistic details of gene regulation and exploring therapeutic interventions targeting NF-κB activity.
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