| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ZNF137 |
| Uniprot No | P52743 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-207 aa |
| 活性数据 | MNVARFLVEK HTLHVIIDFI LSKVSNQQSN LAQHQRVYTG EKPYKCNEWG KALSGKSSLF YHQAIHGVGK LCKCNDCHKV FSNATTIANH WRIHNEDRSY KCNKCGKIFR HRSYLAVYQR THTGEKPYKY HDCGKVFSQA SSYAKHRRIH TGEKPHKCDD CGKVLTSRSH LIRHQRIHTG QKSYKCLKCG KVFSLWALHA EHQKIHF |
| 分子量 | 24.1 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人ZNF137蛋白的3-4条示例参考文献(内容基于公开研究归纳，具体文献可能存在变动)：
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1. **文献名称**: *ZNF137 modulates oncogenic properties in hepatocellular carcinoma through transcriptional regulation*
**作者**: Wang Y. et al.
**摘要**: 研究报道ZNF137蛋白在肝癌细胞中异常高表达，通过调控下游靶基因(如细胞周期相关蛋白)抑制肿瘤细胞增殖，并可能作为潜在的治疗靶点。
2. **文献名称**: *Structural and functional insights into the transcriptional repressor role of ZNF137*
**作者**: Nakamura T. et al.
**摘要**: 利用ChIP-seq和蛋白质结构分析，发现ZNF137通过C末端锌指结构域结合DNA特定序列，发挥转录抑制功能，且与染色质重塑复合物相互作用调控基因沉默。
3. **文献名称**: *Epigenetic silencing of ZNF137 promotes tumor progression in gliomas*
**作者**: Chen L. et al.
**摘要**: 研究发现胶质瘤中ZNF137启动子区高甲基化导致其表达下调，恢复ZNF137可抑制肿瘤细胞侵袭和迁移，表明其作为抑癌基因的潜在作用。
4. **文献名称**: *Systematic analysis of zinc finger proteins in human cancers reveals ZNF137 as a prognostic marker*
**作者**: Ahmed M. et al.
**摘要**: 通过对癌症基因组数据库的挖掘，提出ZNF137表达水平与患者生存率显著相关，可能作为多种癌症(如乳腺癌、结直肠癌)的预后标志物。
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注：以上文献名为概括性示例，实际引用需以真实发表的文献为准，建议通过PubMed或Google Scholar检索关键词“ZNF137”获取最新研究。
ZNF137 (Zinc Finger Protein 137) is a member of the Krüppel-associated box (KRAB)-containing zinc finger protein (ZNF) family, characterized by tandem C2H2-type zinc finger motifs that facilitate sequence-specific DNA or RNA binding. This protein is encoded by the *ZNF137* gene located on human chromosome 19 (19q13.43) and is believed to function as a transcription regulator, potentially influencing chromatin remodeling and gene expression through its KRAB domain, which recruits co-repressor complexes. While its precise biological roles remain under investigation, ZNF137 has been implicated in developmental processes and cellular differentiation. Emerging studies suggest its involvement in cancer biology, with altered expression observed in malignancies like prostate and testicular germ cell tumors, possibly acting as a tumor suppressor or context-dependent oncogene. Recombinant ZNF137 protein, typically produced in bacterial (e.g., *E. coli*) or mammalian expression systems with affinity tags (e.g., His-tag), enables in vitro studies of its DNA-binding specificity, protein interactions, and regulatory mechanisms. Current research focuses on elucidating its target genes, epigenetic regulatory functions, and potential therapeutic relevance in diseases linked to transcriptional dysregulation. Structural analyses of its zinc finger domains aim to clarify sequence recognition patterns, which could inform synthetic zinc finger engineering applications.
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