Cat: PA2000-3185

Recombinant Human LAMTOR1 Protein,His

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关键信息

  • 基因名

    LAMTOR1

  • 应用

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    LAMTOR1;C11orf59;PDRO;Ragulator complex Protein LAMTOR1

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    His tag N-Terminus

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    Q6IAA8

  • 表达区间

    2-161aa

  • 氨基酸序列

    GCCYSSENEDSDQDREERKLLLDPSSPPTKALNGAEPNYHSLPSARTDEQALLSSILAKTASNIIDVSAADSQGMEQHEYMDRARQYSTRLAVLSSSLTHWKKLPPLPSLTSQPHQVLASEPIPFSDLQQVSRIAAYAYSALSQIRVDAKEELVVQFGIP

  • 分子量

    21.7 kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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背景信息

LAMTOR1 (Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1) is a crucial component of the cellular machinery that regulates signaling pathways related to mTOR (mechanistic target of rapamycin) and MAPK (mitogen-activated protein kinase). It plays a pivotal role in the formation of the mTORC1 (mTOR complex 1) signaling complex, which is essential for cellular growth, proliferation, and metabolism. The study of LAMTOR1 and its recombinant protein has gained traction due to its involvement in various physiological and pathological processes, including cancer, neurodegenerative diseases, and metabolic disorders. Understanding LAMTOR1's function and interactions with other proteins could unveil novel therapeutic targets. The research focuses not only on elucidating the molecular mechanisms of LAMTOR1 in cellular signaling but also on developing recombinant protein for functional studies and potential drug discovery. Investigating the structure, function, and regulation of LAMTOR1 may provide insights into its role in lysosomal function and homeostasis, which is critical for the maintenance of cellular health. As such, recombinant LAMTOR1 could be instrumental in both basic research and clinical applications, including the development of targeted therapies aimed at diseases where this signaling pathway is dysregulated. The ongoing exploration of LAMTOR1's roles in various biological contexts underscores the importance of this adaptor protein in understanding cellular dynamics and advancing medical research.

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