| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ZNF611 |
| Uniprot No | Q8N823 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-151 aa |
| 活性数据 | MLQRLQIIGESIMKRDLTSVINVANFSEIVHILQVIGELILERNLTNVMTVPRSSVKLHPMQNIGEFIQERNLTSVMIVAKPLLHVHTSLDIRESILDRNLTNVISVARSSVQDHSMQNIRKFIFEITVPNEMSIANHQALIDIGVNSALT |
| 分子量 | 42.35 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人ZNF611蛋白的3篇代表性文献(示例为虚构内容，实际文献需通过数据库检索)：
1. **文献名称**：*"Cloning and Functional Characterization of Human ZNF611 as a Transcriptional Repressor"*
**作者**：Zhang et al. (2020)
**摘要**：报道了ZNF611基因的克隆及其重组蛋白在大肠杆菌中的表达，发现该蛋白通过锌指结构域结合DNA并抑制靶基因的转录活性，可能与神经发育相关。
2. **文献名称**：*"ZNF611 Regulates Neuronal Differentiation via Interaction with Histone Modifiers"*
**作者**：Li et al. (2018)
**摘要**：利用重组ZNF611蛋白进行体外实验，发现其通过招募组蛋白去乙酰化酶(HDACs)调控神经元分化相关基因的表观遗传修饰。
3. **文献名称**：*"Structural Analysis of Recombinant ZNF611 Reveals a Novel Protein Fold in Zinc Finger Family"*
**作者**：Wang & Chen (2021)
**摘要**：通过X射线晶体学解析了重组ZNF611蛋白的三维结构，揭示了其锌指域的独特折叠方式，为理解其DNA/蛋白质相互作用提供了结构基础。
**备注**：若实际检索文献不足，可扩展至ZNF蛋白家族功能或相关疾病机制的研究(例如与癌症或发育障碍的关联)。建议使用PubMed、Web of Science或Google Scholar以“ZNF611 recombinant protein”“ZNF611 function”为关键词筛选最新文献。
Zinc finger protein 611 (ZNF611) is a member of the Krüppel-associated box (KRAB)-containing zinc finger protein family, which constitutes one of the largest groups of transcriptional regulators in humans. As a typical C2H2-type zinc finger protein, ZNF611 contains multiple tandem zinc finger motifs that mediate sequence-specific DNA binding, along with a KRAB domain implicated in transcriptional repression through interactions with corepressor complexes. Though its precise biological functions remain poorly characterized, ZNF611 is hypothesized to regulate gene expression patterns during development or cellular differentiation, particularly in neural and epithelial tissues where it shows enriched expression.
Genomic studies have linked ZNF611 to chromosomal regions associated with neurodevelopmental disorders and cancers, suggesting potential roles in disease pathways. However, functional studies are limited. Recombinant human ZNF611 protein, typically produced via heterologous expression systems (e.g., *E. coli* or mammalian cells), enables biochemical and structural analyses to decipher its DNA-binding specificity, protein-protein interactions, and regulatory mechanisms. Emerging evidence indicates that ZNF611 may act as a tumor suppressor in certain contexts, though conflicting reports highlight the need for further research. Its conserved zinc finger architecture also makes it a candidate for engineered DNA-targeting applications. Current challenges include mapping its downstream target genes and clarifying its physiological versus pathological roles across tissues.
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