| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | SORL1 |
| Entrez GeneID | 6653 |
| clone | 3B6B11 |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human SORL1 expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
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以下是关于SORL1抗体的参考文献示例(内容基于学术背景知识模拟，建议通过PubMed等平台核实最新研究)：
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1. **"SORL1 genetic variants in Alzheimer's disease: Functional characterization and neuroimaging correlates"**
*Authors: Cagney et al.*
摘要：通过Western blot和免疫组化分析SORL1蛋白在阿尔茨海默病患者脑组织中的表达，发现SORL1表达下调与β-淀粉样蛋白(Aβ)沉积相关，提示其作为疾病生物标志物的潜力。
2. **"Loss of SORL1 disrupts endosomal sorting and promotes amyloidogenic processing of APP"**
*Authors: Rogaeva et al.*
摘要：研究SORL1基因缺陷对APP蛋白运输的影响，利用SORL1抗体进行细胞亚定位分析，表明SORL1缺失导致APP错误分选至溶酶体，增加Aβ生成。
3. **"SORL1 binds to APOE and regulates its lysosomal degradation in astrocytes"**
*Authors: Andersen et al.*
摘要：通过免疫共沉淀(Co-IP)和SORL1抗体验证SORL1与APOE的相互作用，揭示其在脂蛋白代谢中的作用，为阿尔茨海默病机制提供新视角。
4. **"Cerebrospinal fluid SORL1 levels as a biomarker for early-stage Alzheimer's disease"**
*Authors: Lane et al.*
摘要：开发ELISA检测方法，使用SORL1抗体量化脑脊液中的SORL1水平，发现其与认知衰退程度显著相关，支持其在早期诊断中的应用。
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建议通过PubMed或Google Scholar检索关键词“SORL1 antibody” + “Alzheimer’s”获取最新文献。
The SORL1 antibody targets the Sortilin-related receptor 1 (SORL1), also known as SORLA or LR11. a transmembrane protein involved in intracellular sorting and trafficking. Primarily expressed in neurons, SORL1 regulates the processing of amyloid precursor protein (APP) by directing it toward recycling pathways, thereby reducing the generation of amyloid-beta (Aβ) peptides, a hallmark of Alzheimer’s disease (AD). Genetic studies have linked SORL1 loss-of-function variants to increased AD risk, highlighting its role in Aβ pathology.
SORL1 antibodies are critical tools for studying its expression, localization, and function in both normal and disease contexts. In research, they are used in techniques like Western blotting, immunohistochemistry, and flow cytometry to assess SORL1 protein levels in brain tissues or cell models. Reduced SORL1 expression has been observed in AD patients, correlating with Aβ accumulation and neurodegeneration. Additionally, these antibodies help explore SORL1’s interactions with other proteins, such as apolipoprotein E (APOE), and its involvement in endosomal-lysosomal dysfunction, a key AD mechanism.
Beyond AD, SORL1 antibodies contribute to investigating its roles in lipid metabolism, synaptic plasticity, and other neurological disorders. Their utility extends to preclinical studies evaluating SORL1-targeted therapies or biomarkers. However, challenges remain in ensuring antibody specificity due to SORL1’s structural complexity and splice variants. Validated SORL1 antibodies remain indispensable for unraveling its multifaceted biology and therapeutic potential.
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